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Oxidation of protein kinase a regulatory subunit PKARIα protects against myocardial ischemia-reperfusion injury by inhibiting lysosomal-triggered calcium release

Abstract:

Background: Kinase oxidation is a critical signalling mechanism through which changes in the intracellular redox state alter cardiac function. In the myocardium, type-1 protein kinase A (PKARIα) can be reversibly oxidized, forming interprotein disulfide bonds within the holoenzyme complex. However, the effect of PKARIα disulfide formation on downstream signaling in the heart, particularly under states of oxidative stress such as ischemia and reperfusion (I/R), remains unex...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/circulationaha.120.046761

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0001-8140-7782
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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Lippincott, Williams & Wilkins Publisher's website
Journal:
Circulation Journal website
Volume:
143
Issue:
5
Pages:
449–465
Place of publication:
United States
Publication date:
2020-11-13
Acceptance date:
2020-11-09
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Pmid:
33185461
Language:
English
Keywords:
Pubs id:
1146125
Local pid:
pubs:1146125
Deposit date:
2020-11-30

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