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Four step total synthesis of an H3 receptor antagonist using only tools found in a typical teaching laboratory

Abstract:

Organic synthesis in a modern research laboratory uses state-of-the-art equipment to provide inert atmospheres, track reaction progress, and facilitate the purification of intermediates. Such facilities are not available in a high school laboratory. In this paper, synthetic organic chemistry is taken back to basics: A four step total synthesis of a potential histamine H3 receptor antagonist is completed by A-level students in a school laboratory using only basic equipment. In addition to its ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.jchemed.7b00982

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0002-4149-0494
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Somerville College
Role:
Author
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Chemical Education Journal website
Volume:
96
Issue:
1
Pages:
137-142
Publication date:
2018-12-14
Acceptance date:
2018-11-20
DOI:
EISSN:
1938-1328
ISSN:
0021-9584
Source identifiers:
963105
Keywords:
Pubs id:
pubs:963105
UUID:
uuid:5e715d27-0f0e-4e68-8ec2-d52025fd29ac
Local pid:
pubs:963105
Deposit date:
2019-02-18

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