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Thesis

Syncrip regulates mRNA localisation and translation at the drosophila neuromuscular junction

Abstract:

Evidence in different systems suggests that local translation is involved in synaptic plasticity in both neuron and muscle, but the mechanism by which this occurs is still poorly understood. The mRNA-binding protein Syncrip is conserved from fly to mammals and is thought to be involved in localized translation in both oocytes and neurons. Previous work has shown that Syncrip associates with mRNAs encoding key synaptic proteins at the Drosophila larval neuromuscular junction. Here I show th...

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Division:
MSD
Department:
Biochemistry
Research group:
Prof. Ilan Davis Group
Oxford college:
Queen's College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
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Funding agency for:
Halstead, J
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:5e9040a3-a9d3-40e9-adf6-d9dae0e9ec09
Local pid:
ora:7633
Deposit date:
2013-12-09

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