Journal article
Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.
- Abstract:
-
Lentiviral Nef increases T cell signaling activity, but the molecular nature of the stimulus involved is incompletely described. We explored CD4 T cell lipid raft composition in the presence and absence of Nef. Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjunction with c-Cbl, is absent from lipid rafts. This Nef-mediated exclusion is associated with failure of ubiquitination of activated Vav. In the presence of Nef, lipid raft Cdc42 is activated and forms a ternary comple...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1016/j.immuni.2005.11.003
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Authors
Funding
Medical Research Council
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Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Immunity Journal website
- Volume:
- 23
- Issue:
- 6
- Pages:
- 621-634
- Publication date:
- 2005-12-01
- DOI:
- EISSN:
-
1097-4180
- ISSN:
-
1074-7613
- Source identifiers:
-
33330
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:33330
- UUID:
-
uuid:5ec7ef78-fc9f-4987-9e32-55e32b09f484
- Local pid:
- pubs:33330
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2005
- Notes:
- The full text of this article is available open access on the publisher's website at http://www.sciencedirect.com/science/article/pii/S1074761305003766
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