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Induction of tryptophan 2,3-dioxygenase expression in human monocytic leukemia/lymphoma cell lines THP-1 and U937

Abstract:

Tumor-associated macrophages are immune cells with diverse functions in tumor development. Among other functions, they downregulate immune-mediated tumor rejection by depriving lymphocytes of nutrients. The essential amino acid tryptophan is metabolized by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase (TDO). Indoleamine 2,3-dioxygenase 1 is expressed in a large number of human tumors, and inhibitors are in development to improve immunotherapy. Tryptophan 2,3-dioxyge...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/1178646919891736

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
ORCID:
0000-0002-4995-3270
Publisher:
SAGE Publications Publisher's website
Journal:
International Journal of Tryptophan Research Journal website
Volume:
12
Pages:
1-8
Publication date:
2019-12-26
Acceptance date:
2019-11-01
DOI:
EISSN:
1178-6469
Source identifiers:
1080731
Language:
English
Keywords:
Pubs id:
pubs:1080731
UUID:
uuid:5eee849e-e815-46f3-a9db-18843223bc37
Local pid:
pubs:1080731
Deposit date:
2020-01-02

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