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Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

Abstract:

BACKGROUND:Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS:A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103,357 Europeans with established CHD at baseline from the GENIUS-CHD Consortium (73.1% male, mean age 62.9 years). The...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/circgen.119.002471

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Publisher:
American Heart Association Publisher's website
Journal:
Circulation: Genomic and Precision Medicine Journal website
Volume:
12
Issue:
4
Pages:
161-172
Publication date:
2019-03-21
Acceptance date:
2019-03-18
DOI:
ISSN:
2574-8300
Pmid:
30897348
Source identifiers:
983985
Language:
English
Keywords:
Pubs id:
pubs:983985
UUID:
uuid:5ef69c52-32c8-4e58-9825-f34a84457793
Local pid:
pubs:983985
Deposit date:
2019-04-30

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