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Journal article

Pumping Ca2+ up H+ gradients: a Ca2+-H+ exchanger without a membrane

Abstract:

Cellular processes are exquisitely sensitive to H+ and Ca2+ ions because of powerful ionic interactions with proteins. By regulating the spatial and temporal distribution of intracellular [Ca2+] and [H+], cells such as cardiac myocytes can exercise control over their biological function. A well-established paradigm in cellular physiology is that ion concentrations are regulated by specialized, membrane-embedded transporter proteins. Many of these couple the movement of two or more ionic speci...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1113/jphysiol.2013.265959

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
British Heart Foundation More from this funder
Royal Society More from this funder
Publisher:
Wiley Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
592
Issue:
15
Pages:
3179-3188
Publication date:
2014-02-10
Acceptance date:
2014-02-02
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
481154
Pubs id:
pubs:481154
UUID:
uuid:5f04247c-ba2d-4a72-8d15-6293c81b292b
Local pid:
pubs:481154
Deposit date:
2014-08-29

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