Journal article
Pumping Ca2+ up H+ gradients: a Ca2+-H+ exchanger without a membrane
- Abstract:
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Cellular processes are exquisitely sensitive to H+ and Ca2+ ions because of powerful ionic interactions with proteins. By regulating the spatial and temporal distribution of intracellular [Ca2+] and [H+], cells such as cardiac myocytes can exercise control over their biological function. A well-established paradigm in cellular physiology is that ion concentrations are regulated by specialized, membrane-embedded transporter proteins. Many of these couple the movement of two or more ionic speci...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 1.7MB)
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- Publisher copy:
- 10.1113/jphysiol.2013.265959
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Authors
Funding
British Heart Foundation
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Royal Society
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Journal of Physiology Journal website
- Volume:
- 592
- Issue:
- 15
- Pages:
- 3179-3188
- Publication date:
- 2014-02-10
- Acceptance date:
- 2014-02-02
- DOI:
- EISSN:
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1469-7793
- ISSN:
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0022-3751
- Source identifiers:
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481154
Item Description
- Pubs id:
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pubs:481154
- UUID:
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uuid:5f04247c-ba2d-4a72-8d15-6293c81b292b
- Local pid:
- pubs:481154
- Deposit date:
- 2014-08-29
Terms of use
- Copyright holder:
- Swietach et al
- Copyright date:
- 2014
- Notes:
- © 2014 The Authors. The Journal of Physiology © 2014 The Physiological Society. This is the author accepted manuscript following peer review version of the article. The final version is available online from Wiley at: dx.doi.org/10.1113/jphysiol.2013.265959
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