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Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis. A longitudinal clinical and MRI study.

Abstract:

Metalloproteinases have been implicated in the pathogenesis of multiple sclerosis. We report longitudinal serum levels of gelatinase B and of the tissue inhibitors of matrix metalloproteinases (TIMP), TIMP-1 and TIMP-2, in 21 patients with relapsing multiple sclerosis. Patients had monthly clinical and gadolinium-enhanced MRI follow-up for 10 months. Longitudinal samples in nine healthy controls and cross-sectional samples from 12 patients with inflammatory CNS disease and 15 patients with ot...

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Publication status:
Published

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Publisher copy:
10.1093/brain/122.2.191

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Journal:
Brain : a journal of neurology
Volume:
122 ( Pt 2)
Issue:
2
Pages:
191-197
Publication date:
1999-02-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Source identifiers:
387049

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