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Journal article

Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae.

Abstract:
TEM-1 is the dominant β-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 carries a Tn3 resolvase gene and pA1606 and pA1209 carry an open reading frame (ORF) similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd to the ampicillin-resistant phenotype.

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Publisher copy:
10.1128/aac.00408-12

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
56
Issue:
9
Pages:
4958-4960
Publication date:
2012-09-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Source identifiers:
386886

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