Journal article icon

Journal article

Synthesis of the C50 diastereomers of the C33-C51 fragment of stambomycin D

Abstract:
As products of genome mining, the stereochemical assignment of the macrolide antibiotics stambomycins A–D has been made on the basis of sequence analysis of the associated polyketide synthase, aside from two stereocentres at C28 and C50. Here we describe syntheses of the two C50 diastereomers of the C33–C51 region of the stambomycins, which support the PKS-based configurational assignment, and establish a strategy suitable for access to the extended stambomycin framework.
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1039/d1qo01635k

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0002-4149-0494
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Organic Chemistry Frontiers Journal website
Volume:
9
Pages:
445-449
Publication date:
2021-12-08
Acceptance date:
2021-12-08
DOI:
EISSN:
2052-4129
Language:
English
Keywords:
Pubs id:
1232520
Local pid:
pubs:1232520
Deposit date:
2022-01-24

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP