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Journal article

Global and regional estimates for subtype-specific therapeutic and prophylactic HIV-1 vaccines: a modelling study

Abstract:

Global HIV-1 genetic diversity forms a major obstacle to the development of an HIV vaccine. It may be necessary to employ subtype-specific HIV-1 vaccines in individual countries according to their HIV-1 subtype distribution. We estimated the global and regional need for subtype-specific HIV-1 vaccines. We took into account the proportions of different HIV-1 variants circulating in each country, the genetic composition of HIV-1 recombinants, and the different genome segments (gag, pol, env) th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fmicb.2021.690647

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
ORCID:
0000-0002-7801-5777
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Contributors

Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Microbiology Journal website
Volume:
12
Article number:
690647
Publication date:
2021-07-15
Acceptance date:
2021-05-27
DOI:
EISSN:
1664-302X
Language:
English
Keywords:
Pubs id:
1181285
Local pid:
pubs:1181285
Deposit date:
2021-06-09

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