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Thesis

TCR signalling in response to affinity stimulation

Abstract:

T cells are an essential part of the adaptive immune system and protect the body from intracellular infections. The specificity with which αßTCR-bearing T cells recognize cognate antigen presented on MHC molecules is paramount to maintaining the balance between mounting effector functions against pathogens and establishing peripheral tolerance to self. The mechanism by which T cells translate qualitative differences in TCR:pMHC binding to sensitive proximal signalling events which ultimate...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Prof Oreste Acuto
Oxford college:
Lincoln College
Role:
Author
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Division:
MSD
Department:
Pathology Dunn School
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
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Funding agency for:
Bruger, A
Grant:
BVRTEM0
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:5f9c1001-6c43-472f-a495-c9573b54a84a
Local pid:
ora:10454
Deposit date:
2015-03-05

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