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Morphological analysis of human umbilical vein endothelial cells co-cultured with ovarian cancer cells in 3D: an oncogenic angiogenesis assay

Abstract:

Antiangiogenic therapy for cancer is a strategy targeted at tumour vasculature, often in combination with conventional cytotoxicity treatments. Animal testing is still the most common method used for evaluating the efficacy of new drugs but tissue-engineered in vitro models are becoming more acceptable for replacing and reducing the use of animals in anticancer drug screening. In this study, a 3D co-culture model of human endothelial cells and ovarian cancer cells was developed. This model ha...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0180296

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Linacre College
Role:
Author
More from this funder
Funding agency for:
Bovornchutichai, P
More from this funder
Funding agency for:
O'Neill, E
Grant:
A19277
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Funding agency for:
Wan, X
China-Oxford Scholarship Fund More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
7
Article number:
e0180296
Publication date:
2017-07-03
Acceptance date:
2017-06-14
DOI:
ISSN:
1932-6203
Source identifiers:
701382
Keywords:
Pubs id:
pubs:701382
UUID:
uuid:5f9d10be-f42d-4600-80a6-7de2cec096f9
Local pid:
pubs:701382
Deposit date:
2017-06-20

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