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Thesis

Detection and characterization of HIV-1 specific T cell responses amongst exposed and unexposed HIV-1 seronegative individuals

Abstract:

The primary aim of this thesis was to examine whether HIV-1 specific T cell responses in HIV-1 exposed seronegative (HESN) subjects could be firstly detected and if so, conferred protection against productive infection from HIV-1.

Cultured IFN-γ ELISpot found 38.7-60% of HESN subjects had detectable HIV-1 specific T cell responses. HIV-1 specific T cell responses could be titrated, were typically mediated by CD4+ T cells and tended to map to previously defined, promiscuous epitopes....

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Research group:
CHAVI Group
Oxford college:
Brasenose College
Role:
Author

Contributors

Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:5fd7fca5-96bd-42c6-ac71-74c553efa2ed
Deposit date:
2016-11-15

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