Journal article icon

Journal article

How driving endonuclease genes can be used to combat pests and disease vectors

Abstract:

Driving endonuclease genes (DEGs) spread through a population by a non-Mendelian mechanism. In a heterozygote, the protein encoded by a DEG causes a double-strand break in the homologous chromosome opposite to where its gene is inserted and when the break is repaired using the homologue as a template the DEG heterozygote is converted to a homozygote. Some DEGs occur naturally while several classes of endonucleases can be engineered to spread in this way, with CRISPR-Cas9 based systems being p...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1186/s12915-017-0420-4

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0001-8859-7232
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Zoology
Role:
Author
Bill and Melinda Gates Foundation More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Biology Journal website
Volume:
15
Issue:
1
Article number:
81
Publication date:
2017-09-11
DOI:
ISSN:
1741-7007
Pmid:
28893259
Source identifiers:
730139
Language:
English
Keywords:
Pubs id:
pubs:730139
UUID:
uuid:5ff58a16-a641-43b0-934c-3c6798707237
Local pid:
pubs:730139
Deposit date:
2017-12-08

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP