Journal article
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
- Abstract:
-
Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 10
- Issue:
- 1
- Article number:
- 4130
- Publication date:
- 2019-09-11
- Acceptance date:
- 2019-07-23
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
31511532
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1053312
- Local pid:
- pubs:1053312
- Deposit date:
- 2020-04-07
Terms of use
- Copyright holder:
- Teumer et al.
- Copyright date:
- 2019
- Rights statement:
- Copyright © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record