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Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Abstract:

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-11576-0

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Role:
Author
ORCID:
0000-0002-8309-094X
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Role:
Author
ORCID:
0000-0003-2651-8791
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Role:
Author
ORCID:
0000-0001-5774-034X
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Role:
Author
ORCID:
0000-0003-3420-5082
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Publisher:
Nature Research Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Issue:
1
Article number:
4130
Publication date:
2019-09-11
Acceptance date:
2019-07-23
DOI:
EISSN:
2041-1723
Pmid:
31511532

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