Journal article
Expansion of Foxp3(+) T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge.
- Abstract:
-
Candida albicans remains the fungus most frequently associated with nosocomial bloodstream infection. In disseminated candidiasis, the role of Foxp3(+) regulatory T (Treg) cells remains largely unexplored. Our aims were to characterize Foxp3(+) Treg-cell activation in a murine intravenous challenge model of disseminated C. albicans infection, and determine the contribution to disease. Flow cytometric analyses demonstrated that C. albicans infection drove in vivo expansion of a splenic CD4(+) ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/eji.201343604
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Bibliographic Details
- Journal:
- European journal of immunology
- Volume:
- 44
- Issue:
- 4
- Pages:
- 1069-1083
- Publication date:
- 2014-04-01
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- Source identifiers:
-
465771
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:465771
- UUID:
-
uuid:60211384-0e9f-456d-a4b8-5725491a072a
- Local pid:
- pubs:465771
- Deposit date:
- 2014-06-17
Terms of use
- Copyright date:
- 2014
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