Thesis
Targeting polymer coated adenovirus to tumour-associated vasculature
- Abstract:
-
Tumour-associated vasculature provides an accessible target for systemic gene therapy using targeted adenoviruses. The aim of this thesis is to develop strategies for targeting adenovirus infection to tumour-associated endothelium.
Adenovirus expressing luciferase (Adluc) was coated with an amino-reactive polymer based on poly [N-(2-hydroxypropyl) methacrylamide] [pHPMA] to ablate normal infection pathways¬. This was a pre-requisite to redirecting virus tropism to infect endothelia...
Expand abstract
Actions
Bibliographic Details
- Publication date:
- 2010
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:602123e8-814c-4b63-a482-ab8adcfa6594
- Local pid:
- ora:5644
- Deposit date:
- 2011-08-18
Terms of use
- Copyright holder:
- Bachtarzi, H
- Copyright date:
- 2010
- Notes:
- This thesis is not available in ORA.
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record