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Thesis

Design, synthesis and biological evaluation of glycosidase inhibitors in an anti-cancer setting

Abstract:

The aim of the work described in this thesis was to explore the synthesis of glycosidase inhibitors and to evaluate their potential as anti-cancer agents. Glycosidases catalyze the fission of glycosidic bonds and are involved in vital biological functions. With regard to their potential for anti-cancer therapy, two glycosidases were identified: α-N-acetyl-galactosaminidase and β-N-acetyl-hexosaminidase. The former has been implicated in causing immunosuppression in advanced cancer...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Prof. G. W. J. Fleet Group, Dr. T. Butters Group
Oxford college:
St John's College
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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