Journal article
Asymmetric synthesis of nortropanes via Rh-catalyzed allylic arylation
- Abstract:
-
Tropane derivatives are extensively used in medicine, but catalytic asymmetric methods for their synthesis are underexplored. Here we report Rh-catalyzed asymmetric Suzuki-Miyaura type cross-coupling reactions between a racemic N-Bocnortropane-derived allylic chloride and (hetero-)aryl-boronic esters. The reaction proceeds via an unexpected kinetic resolution, and the resolved enantiopure allyl chloride can undergo highly enantiospecific reactions with N, O, and S-containing nucleophiles. The...
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- Publication status:
- Accepted
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- ACS Catalysis Journal website
- Acceptance date:
- 2022-06-28
- EISSN:
-
2155-5435
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1266517
- Local pid:
- pubs:1266517
- Deposit date:
- 2022-07-04
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