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Thesis

Phenotypic models of perfect adaptation by CD8+ T cells

Abstract:

T cells receive continuous antigenic stimulation in peripheral tolerance, cancer, and chronic infection. Persistent antigen exposure induces an initial cellular response. However, over time, T cells become unresponsive to the stimulus and cease activity, a behaviour known as adaptation. Although it is generally known that T cells adapt to persistent stimuli, the properties of this adaptation remain understudied. This thesis aims to characterize phenotypes of T cell adaptation and to sugges...

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Division:
MSD
Department:
Pathology Dunn School
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:60b24cb7-bf97-4577-b283-2bb280d99320
Deposit date:
2020-03-02

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