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Molecular Genetic Studies of Pancreatic Neuroendocrine Tumors: New Therapeutic Approaches

Abstract:

Pancreatic neuroendocrine tumors (PNETs) can occur as sporadic neoplasms or as part of hereditary syndromes such as multiple endocrine neoplasia type 1 (MEN1). MEN1, which is an autosomal dominant disorder, is due to loss-of-function mutations of the tumor suppressor MEN1 gene that encodes menin. Approximately 40% of nonfamilial (ie, sporadic) PNETs have MEN1 mutations, with subsequent loss of menin, which acts as a tumor suppressor. Menin is a scaffold protein with roles in transcriptional r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ecl.2018.04.007

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
Keble College
Role:
Author
Publisher:
Elsevier Publisher's website
Host title:
Endocrinology and Metabolism Clinics of North America
Publication date:
2018-08-08
DOI:
ISSN:
0889-8529
Source identifiers:
857229
Keywords:
Pubs id:
pubs:857229
UUID:
uuid:60df3b77-b1b7-4623-80a0-57ba33ce58d9
Local pid:
pubs:857229
Deposit date:
2018-06-15

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