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An analysis of non-coding RNAs in Plasmodium falciparum and their potential role in antigenic variation

Abstract:

A major virulence factor of the human malaria parasite Plasmodium falciparum is Plasmodium falciparum erythrocyte membrane protein 1(PfEMP-1). This protein is inserted into the erythrocyte membrane, giving cytoadherence properties. A family of genes called var, located sub-telomerically and in chromosome central clusters encode this protein. Var genes are expressed in a mutually exclusive manner, how this is controlled is unclear. A non-coding RNA (ncRNA...

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Division:
MSD
Department:
RDM
Research group:
Molecular Parasitology Group
Oxford college:
St Catherine's College
Role:
Author

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Division:
MSD
Department:
NDM
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:60ea27e2-1129-4914-8abd-cfad018e0353
Local pid:
ora:7187
Deposit date:
2013-08-15

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