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The role of astrocytes in brain metastasis

Abstract:

Brain metastasis is a significant clinical problem, and 20-40% of cancer patients will develop metastatic spread to the brain.There remains, however, an urgent need to better understand the pathogenesis of brain metastasis and, in particular, the contribution of the tumour microenvironment. Astrocytes are activated in response to metastatic growth and in vitro studies suggest that this activation promotes tumour growth and invasion. However, the result of astrocyte activation ha...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Research group:
Experimental Neuroimaging
Oxford college:
Jesus College
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:60efc7bd-4f00-4e84-a964-c4ef55009dfb
Local pid:
ora:11894
Deposit date:
2015-07-27

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