Journal article
The biogenesis and characterization of mammalian microRNAs of mirtron origin.
- Abstract:
-
Mirtrons, short hairpin pre-microRNA (miRNA) mimics directly produced by intronic splicing, have recently been identified and experimentally confirmed in invertebrates. While there is evidence to suggest several mammalian miRNAs have mirtron origins, this has yet to be experimentally demonstrated. Here, we characterize the biogenesis of mammalian mirtrons by ectopic expression of splicing-dependent mirtron precursors. The putative mirtrons hsa-miR-877, hsa-miR-1226 and mmu-miR-1224 were desig...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Nucleic acids research Journal website
- Volume:
- 40
- Issue:
- 1
- Pages:
- 438-448
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:175229
- UUID:
-
uuid:60f4e265-82a7-48d6-b8c0-d3e203db5116
- Local pid:
- pubs:175229
- Source identifiers:
-
175229
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Sibley et al
- Copyright date:
- 2012
- Notes:
- Copyright © 2011 Sibley et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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