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Feasibility, long‐term safety and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients

Abstract:

Short‐term outcomes in kidney transplantation are marred by progressive transplant failure and mortality secondary to immunosuppression toxicity. Immune modulation with autologous polyclonal regulatory T cell (Treg) therapy may facilitate immunosuppression reduction promoting better long‐term clinical outcomes. In a Phase I clinical trial, 12 kidney transplant recipients received 1‐10x106 Treg per kg at Day+5 post transplantation in lieu of induction immunosuppression (Treg Therapy cohort). N...

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Publication status:
Published
Peer review status:
Reviewed (other)

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Publisher copy:
10.1111/ajt.16395

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Role:
Author
ORCID:
0000-0002-3164-6360
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Publisher:
Wiley Publisher's website
Journal:
American Journal of Transplantation Journal website
Volume:
21
Issue:
4
Pages:
1603-1611
Publication date:
2020-11-10
Acceptance date:
2020-10-31
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
Pmid:
33171020
Language:
English
Keywords:
Pubs id:
1145089
Local pid:
pubs:1145089
Deposit date:
2020-11-12

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