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Optimization of Zika virus envelope protein production for ELISA and correlation of antibody titers with virus neutralization in Mexican patients from an arbovirus endemic region

Abstract:
Background: Zika virus (ZIKV) has become a global threat with immediate need for accurate diagnostics, efficacious vaccines and therapeutics. Several ZIKV envelope (Env)-based vaccines have been developed recently. However, many commercially available ZIKV Env are based on the African lineage and produced in insect cells. Here, we sought to produce Asian-lineage ZIKV Env in mammalian cells for research and clinical applications. Methods: We designed various g... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12985-018-1104-6

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Grant:
SBRIInnovateUKgrantsreferences972216,ApplicationNumber:72284– 493233
971557ApplicationNumber:94851-557155
Publisher:
BioMed Central Publisher's website
Journal:
Virology Journal Journal website
Volume:
15
Article number:
193
Publication date:
2018-12-27
Acceptance date:
2018-12-04
DOI:
ISSN:
e1743-422X
Source identifiers:
951449
Keywords:
Pubs id:
pubs:951449
UUID:
uuid:617364e6-8063-4807-8739-d295a0d4e888
Local pid:
pubs:951449
Deposit date:
2018-12-13

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