QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data

Colella, S; Yau, C; Taylor, J; Mirza, G; Butler, H; Clouston, P; Bassett, A; Seller, A; Holmes, C; Ragoussis, J

Journal article

QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data

Abstract:: Array-based technologies have been used to detect chromosomal copy number changes (aneuploidies) in the human genome. Recent studies identified numerous copy number variants (CNV) and some are common polymorphisms that may contribute to disease susceptibility. We developed, and experimentally validated, a novel computational framework (QuantiSNP) for detecting regions of copy number variation from BeadArray™ SNP genotyping data using an Objective Bayes Hidden-Markov Model (OB-HMM). Objective ...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Colella, S., Yau, C., Taylor, J., Mirza, G., Butler, H., Clouston, P., Bassett, A., Seller, A., Holmes, C., & Ragoussis, J. (2007). QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data. Nucleic Acids Research, 35(6), 2013–2025.

MLA Style

Colella, S., et al. “QuantiSNP: an Objective Bayes Hidden-Markov Model to Detect and Accurately Map Copy Number Variation Using SNP Genotyping Data.” Nucleic Acids Research, Publisher's version, vol. 35, no. 6, Oxford University Press, 2007, pp. 2013–25.

Chicago Style

Colella, S, C Yau, J Taylor, G Mirza, H Butler, P Clouston, A Bassett, A Seller, C Holmes, and J Ragoussis. 2007. “QuantiSNP: an Objective Bayes Hidden-Markov Model to Detect and Accurately Map Copy Number Variation Using SNP Genotyping Data.” Nucleic Acids Research 35 (6): 2013–25.
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Publisher copy:: 10.1093/nar/gkm076

Authors

+ Colella, S More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Research group:

Genomics Laboratory

Role:

Author

+ Yau, C More by this author

Institution:

University of Oxford

Division:

MPLS

Department:

Statistics

Research group:

Henry Wellcome Centre for Gene Function

Role:

Author

+ Taylor, J More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Research group:

Bioinformatics

Role:

Author

+ Mirza, G More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Research group:

Genomics Laboratory

Role:

Author

+ Butler, H More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Research group:

Genomics Laboratory

Role:

Author

More authors...

Funding

+ Wellcome Trust More from this funder

Grant:

075491/Z/04/Z

+ Medical Research Council More from this funder

Funding agency for:

Holmes, C

+ Engineering and Physical Sciences Research Council More from this funder

Funding agency for:

Yau, C

Bibliographic Details

Publisher:: Oxford University Press Publisher's website
Journal:: Nucleic Acids Research Journal website
Volume:: 35
Issue:: 6
Pages:: 2013-2025
Publication date:: 2007-03-01
DOI:: 10.1093/nar/gkm076
EISSN:: 1362-4962
ISSN:: 0305-1048

Item Description

Language:: English
Keywords:: QuantiSNP

copy number variants

Objective Bayes Hidden-Markov Model
Subjects:: Statistics (see also social sciences)

Medical Sciences

Genetics (medical sciences)
UUID:: uuid:617962f2-1779-4382-882e-f91a873fbd20
Local pid:: ora:3014
Deposit date:: 2009-11-05

Terms of use

Copyright holder:: Stefano Colella et al
Notes:: Citation: Colella, S. et al. (2007). 'QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data', Nucleic Acids Research, 35(6), 2013-2025. [Available at http://nar.oxfordjournals.org/]. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Licence:: CC Attribution-NonCommercial (CC BY-NC)

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QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data

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Journal article

QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data

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