Journal article
In vitro target validation and in vivo efficacy of p38 MAP kinase inhibition in established chronic collagen-induced arthritis model: a pre-clinical study.
- Abstract:
-
OBJECTIVES: The aim of the present study was to determine the in vivo efficacy of p38 mitogen-activated protein kinase (MAPK) inhibitors, namely GW856553X and GSK678361, in murine models of arthritis. METHODS: The effect of p38 MAPK inhibitors was tested in 2 variants of the collagen-induced arthritis model (CIA) in DBA/1 mice, acute arthritis induced by heterologous collagen and chronic relapsing arthritis induced by homologous collagen. Animals were treated after onset of arthritis. Furthe...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Clinical and experimental rheumatology
- Volume:
- 28
- Issue:
- 2
- Pages:
- 176-185
- Publication date:
- 2010-01-01
- EISSN:
-
1593-098X
- ISSN:
-
0392-856X
- Source identifiers:
-
229634
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:229634
- UUID:
-
uuid:61c35a79-7ff6-4bc5-b11e-1a124f57491e
- Local pid:
- pubs:229634
- Deposit date:
- 2013-11-16
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- Copyright date:
- 2010
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