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In vitro target validation and in vivo efficacy of p38 MAP kinase inhibition in established chronic collagen-induced arthritis model: a pre-clinical study.

Abstract:

OBJECTIVES: The aim of the present study was to determine the in vivo efficacy of p38 mitogen-activated protein kinase (MAPK) inhibitors, namely GW856553X and GSK678361, in murine models of arthritis. METHODS: The effect of p38 MAPK inhibitors was tested in 2 variants of the collagen-induced arthritis model (CIA) in DBA/1 mice, acute arthritis induced by heterologous collagen and chronic relapsing arthritis induced by homologous collagen. Animals were treated after onset of arthritis. Furthe...

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Publication status:
Published

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Journal:
Clinical and experimental rheumatology
Volume:
28
Issue:
2
Pages:
176-185
Publication date:
2010-01-01
EISSN:
1593-098X
ISSN:
0392-856X
Source identifiers:
229634

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