Journal article icon

Journal article

Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

Abstract:

Canonical roles for macrophages in mediating the fibrotic response after a heart attack include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen deposition. Here we reveal that macrophages directly contribute collagen to the forming post-injury scar. Unbiased transcriptomics shows an upregulation of collagens in both zebrafish and mouse macrophages following heart injury. Adoptive transfer of macrophages, from either collagen-tagged zebrafish or adult m...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
https://doi.org/10.1038/s41467-019-14263-2

Authors


Expand authors...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Article number:
600
Publication date:
2020-01-30
Acceptance date:
2019-12-27
DOI:
EISSN:
2041-1723
Source identifiers:
1080826
Language:
English
Keywords:
Pubs id:
pubs:1080826
UUID:
uuid:624f14a4-9405-4e67-9e8d-3709bd2ed117
Local pid:
pubs:1080826
Deposit date:
2020-01-06

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP