Design and synthesis of inositol phosphate-based probes

Thesis

Inositol phosphates play a fundamental role in many intracellular processes. Of particular importance is the role of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] in the protein kinase B (PKB/Akt) signalling pathway. PtdIns(3,4,5)P3 recruits PKB to the cell membrane through binding interactions with its pleckstrin homology (PH) domain. In several human cancers, this signalling pathway is upregulated, resulting in increased cell growth and proliferation. In order to investigate...

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Authors: Slowey, A

• Publication date: 2013
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Inositol; Inositol Pyrophosphate; Inositol Phosphate; Protein Kinase B; Organic Synthesis
• Subjects: Natural products; Biomimetic synthesis; Synthetic organic chemistry; Chemistry & allied sciences; Computational chemistry; Organic chemistry; Organic synthesis; Chemical biology; Membrane proteins