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Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci.

Abstract:

Ankylosing spondylitis (AS) is a common inflammatory arthritis predominantly affecting the axial skeleton. Susceptibility to the disease is thought to be oligogenic. To identify the genes involved, we have performed a genomewide scan in 185 families containing 255 affected sibling pairs. Two-point and multipoint nonparametric linkage analysis was performed. Regions were identified showing "suggestive" or stronger linkage with the disease on chromosomes 1p, 2q, 6p, 9q, 10q, 16q, and 19q. The M...

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Publication status:
Published

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Publisher copy:
10.1086/319509

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Journal:
American journal of human genetics
Volume:
68
Issue:
4
Pages:
918-926
Publication date:
2001-04-01
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Source identifiers:
108913

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