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Journal article

Safety and immunogenicity of heterologous prime-boost immunisation with Plasmodium falciparum malaria candidate vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in healthy Gambian and Kenyan adults.

Abstract:

BACKGROUND: Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified vaccinia Virus Ankara (MVA) vectored vaccines is a strategy recently shown to be capable of inducing strong cell mediated responses against several antigens from the malaria parasite. ChAd63-MVA expressing the Plasmodium falciparum pre-erythrocytic antigen ME-TRAP (multiple epitope string with thrombospondin-related adhesion protein) is a leading malaria vaccine candidate, capable of inducing...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0057726

Authors


Wellcome Trust More from this funder
Medical Research Council More from this funder
National Institute of Health Research Oxford Biomedical Research Centre More from this funder
European and Developing Countries Clinical Trials Partnership More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
8
Issue:
3
Pages:
e57726
Publication date:
2013-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
390923
Language:
English
Keywords:
Pubs id:
pubs:390923
UUID:
uuid:62901e20-802d-4b42-bbea-599c37f2c018
Local pid:
pubs:390923
Deposit date:
2013-11-16

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