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Journal article

Fat-secreted ceramides regulate vascular redox state and influence outcomes in patients with cardiovascular disease

Abstract:

Background: Obesity is associated with increased cardiovascular risk; however, the potential role of dysregulations in the adipose tissue (AT) metabolome is unknown.
Objectives: We explored the role of dysregulation in the AT metabolome on vascular redox signalling and cardiovascular outcomes.
Methods: We screened for metabolites differentially secreted by thoracic (ThAT) and subcutaneous (ScAT) tissue of obese patients with ath... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jacc.2021.03.314

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Journal of the American College of Cardiology Journal website
Volume:
77
Issue:
20
Pages:
2494–2513
Publication date:
2021-05-17
Acceptance date:
2021-03-26
DOI:
ISSN:
0735-1097
Language:
English
Keywords:
Pubs id:
1169867
Local pid:
pubs:1169867
Deposit date:
2021-03-31

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