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Overexpression of ubiquitin-specific peptidase 15 in systemic sclerosis fibroblasts increases response to transforming growth factor β

Abstract:
Objective Ubiquitination of proteins leads to their degradation by the proteasome, and is regulated by ubiquitin ligases and substrate-specific ubiquitin-specific peptidases (USPs). The ubiquitination process also plays important roles in the regulation of cell metabolism and cell cycle. Here, we found that the expression of several USPs is increased in SSc tenosynovial and skin biopsies, and we demonstrated that USP inhibition decreases TGF-β signalling in primary fibroblast... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/rheumatology/key401

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Publisher:
Oxford University Press Publisher's website
Journal:
Rheumatology Journal website
Volume:
58
Issue:
4
Pages:
708–718
Publication date:
2019-01-03
Acceptance date:
2018-11-03
DOI:
EISSN:
1462-0332
ISSN:
1462-0324
Pmid:
30608617
Source identifiers:
960117
Language:
English
Keywords:
Pubs id:
pubs:960117
UUID:
uuid:62dfb1e0-4da1-4d0e-a5c1-887e9e0aef0f
Local pid:
pubs:960117
Deposit date:
2019-01-21

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