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Thesis

Investigation of the role of the NLP and TDP1 chromatin associated proteins in transcription control in Trypanosoma brucei

Abstract:

The African trypanosome Trypanosoma brucei evades the immune system of the mammalian host by periodically switching its surface coat which is made up of Variant Surface Glycoprotein (VSG). T. brucei shows monoallelic expression of one VSG out of a repertoire of ~1200 genes with the active VSG gene expressed from one of ~15 telomeric expression sites (ESs). The mechanism behind the monoallelic exclusion of ESs is unclear.

NLP was identified as a novel and essential A...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Queen's College
Role:
Author

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Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:62fdd635-7b92-493a-ac60-fbda5d0f05ac
Local pid:
ora:5922
Deposit date:
2011-11-18

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