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Journal article

Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control

Abstract:

Background

HLA-B*35 is an HLA allele associated with rapid progression to AIDS. However, a mechanism underlying the detrimental effect of HLA-B*35 on disease outcome remains unknown. Recent studies demonstrated that most prevalent subtype HLA-B*35:01 is a detrimental allele in HIV-1 clade B-infected individuals. We here investigated the effect of mutations within the epitopes on HLA-B*35:01-restricted CD8+ T cells having abilities to suppress HIV-1 replication.

Methods

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ebiom.2018.09.022

Authors


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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
36
Pages:
103-112
Publication date:
2018-09-22
Acceptance date:
2018-09-12
DOI:
EISSN:
2352-3964
Pmid:
30249546
Source identifiers:
923483
Language:
English
Keywords:
Pubs id:
pubs:923483
UUID:
uuid:630e6bcd-e5ec-4528-a2bb-73a8397d31dc
Local pid:
pubs:923483
Deposit date:
2018-10-12

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