Thesis
Investigating high-affinity non-covalent protein-ligand interaction via variants of streptavidin
- Abstract:
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The Streptomyces avidinii protein streptavidin binds the small molecule biotin (vitamin H / B₇) with extraordinary stability, resulting in the streptavidin-biotin interaction being one of the strongest non-covalent interactions known in nature (Kd ~ 10-14 M). The stable and rapid biotin-binding, together with high resistance to heat, pH and proteolysis, has given streptavidin huge utility, both in vivo and in vitro. Accordingly, streptavidin has beco...
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Funding
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Chivers, C
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:631c65ed-08d9-484e-a8df-309a4c95df45
- Local pid:
- ora:5987
- Deposit date:
- 2012-01-06
Terms of use
- Copyright holder:
- Chivers, C
- Copyright date:
- 2011
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