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Dissecting domain-specific functions of the IGF2/M6P receptor

Abstract:

The P-type lectin Mannose 6-phosphate/Insulin-like growth factor 2 receptor (M6P/IGF2R) is a type I trans-membrane protein with 15 homologous extracellular domains that bind several ligands. While domains 3, 5 and 9 bind to Mannose 6-Phosphate (M6P), domain 11 binds to IGF2 (Insulin-like growth factor 2). In mice, igf2r expression is monoallelic and full knock-out of the receptor maternal allele (Igf2r-m/+p) results in developmental abnormalities and neonatal lethality...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author

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Role:
Supervisor
Cancer Research UK More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
UUID:
uuid:63ee7b6a-a619-4d42-973e-e888dc427378
Deposit date:
2018-07-13

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