HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi.

Journal article

Understanding how individuals with a high degree of HIV exposure avoid persistent infection is paramount to HIV vaccine design. Evidence suggests that mucosal immunity, particularly virus-specific CTL, could be critically important in protection against sexually acquired HIV infection. Therefore, we have looked for the presence of HIV-specific CD8+ T cells in cervical mononuclear cells from a subgroup of highly HIV-exposed but persistently seronegative female sex workers in Nairobi. An enzyme...

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Authors: Kaul, R; Plummer, F; Kimani, J; Dong, T; Kiama, P

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 164
• Issue: 3
• Pages: 1602-1611
• Publication date: 2000-02-01
• DOI: 10.4049/jimmunol.164.3.1602
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Immunity, Innate; Interferon-gamma; Histocompatibility Testing; Leukocytes, Mononuclear; Humans; Risk Factors; Peptide Fragments; Cervix Uteri; Kenya; Epitopes, T-Lymphocyte; HIV-1; Mucous Membrane; CD8-Positive T-Lymphocytes; Prostitution; Immunophenotyping; Enzyme-Linked Immunosorbent Assay; Female; Lymphocyte Depletion; HIV Infections