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The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells

Abstract:

Cancer cells are reprogrammed to consume large amounts of glucose to support anabolic biosynthetic pathways. However, blood perfusion and consequently the supply with glucose are frequently inadequate in solid cancers. PEPCK-M (PCK2), the mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK), has been shown by us and others to be functionally expressed and to mediate gluconeogenesis, the reverse pathway of glycolysis, in different cancer cells. Serine and ribose synthesis have be...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1719871115

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Role:
Author
ORCID:
0000-0002-8252-9279
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Role:
Author
ORCID:
0000-0001-8423-8224
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Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences of the United States of America Journal website
Volume:
115
Issue:
24
Pages:
6225-6230
Publication date:
2018-05-29
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
29844165
Source identifiers:
856855
Language:
English
Keywords:
Pubs id:
pubs:856855
UUID:
uuid:64b09a9b-cf2f-4276-a48c-a3a2bdeffa32
Local pid:
pubs:856855
Deposit date:
2018-08-17

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