Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation.

Journal article

T cell antigen recognition requires binding of the T cell receptor (TCR) to a complex between peptide antigen and major histocompatibility complex molecules (pMHC), and this recognition occurs at the interface between the T cell and the antigen-presenting cell. The TCR and pMHC molecules are small compared with other abundant cell surface molecules, and it has been suggested that small size is functionally important. We show here that elongation of both mouse and human MHC class I molecules a...

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Authors: Choudhuri, K; Parker, M; Milicic, A; Cole, D; Shaw, M

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 284
• Issue: 38
• Pages: 26096-26105
• Publication date: 2009-09-01
• DOI: 10.1074/jbc.m109.039966
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Peptides; Lymphocyte Activation; Antigens, CD45; T-Lymphocytes; Humans; Mice, Knockout; Mice; Antigens, CD3; Histocompatibility Antigens Class I; Animals; ZAP-70 Protein-Tyrosine Kinase; Phosphorylation; Receptors, Antigen, T-Cell