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Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation.

Abstract:

T cell antigen recognition requires binding of the T cell receptor (TCR) to a complex between peptide antigen and major histocompatibility complex molecules (pMHC), and this recognition occurs at the interface between the T cell and the antigen-presenting cell. The TCR and pMHC molecules are small compared with other abundant cell surface molecules, and it has been suggested that small size is functionally important. We show here that elongation of both mouse and human MHC class I molecules a...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m109.039966

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Journal:
Journal of biological chemistry
Volume:
284
Issue:
38
Pages:
26096-26105
Publication date:
2009-09-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
21967
Language:
English
Keywords:
Pubs id:
pubs:21967
UUID:
uuid:64b80de8-20c4-448c-8733-26e5507c1ecf
Local pid:
pubs:21967
Deposit date:
2012-12-19

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