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Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping

Abstract:

Infection with Trypanosoma cruzi causes Chagas disease, a major public health problem throughout Latin America. There is no vaccine and the only drugs have severe side effects. Efforts to generate new therapies are hampered by limitations in our understanding of parasite biology and disease pathogenesis. Studies are compromised by the complexity of the disease, the long-term nature of the infection, and the fact that parasites are barely detectable during the chronic stage. In addition, funct...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pntd.0006388

Authors


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Role:
Author
ORCID:
0000-0001-7108-3278
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Funding agency for:
Calderano, SG
Grant:
2016/21283-9
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Funding agency for:
Beneke, T
Grant:
15/16_MSD_836338
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Funding agency for:
Lewis, MD
Grant:
625810
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
12
Issue:
4
Article number:
e0006388
Publication date:
2018-04-02
Acceptance date:
2018-03-14
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Pmid:
29608569
Source identifiers:
834032
Language:
English
Pubs id:
pubs:834032
UUID:
uuid:64dcee91-bcd7-482d-a7b9-6b666e02916b
Local pid:
pubs:834032
Deposit date:
2018-05-09

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