Journal article
Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping
- Abstract:
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Infection with Trypanosoma cruzi causes Chagas disease, a major public health problem throughout Latin America. There is no vaccine and the only drugs have severe side effects. Efforts to generate new therapies are hampered by limitations in our understanding of parasite biology and disease pathogenesis. Studies are compromised by the complexity of the disease, the long-term nature of the infection, and the fact that parasites are barely detectable during the chronic stage. In addition, funct...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 13.6MB)
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- Publisher copy:
- 10.1371/journal.pntd.0006388
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Authors
Funding
+ Fundação de Amparo à Pesquisa do Estado de São Paulo
More from this funder
Funding agency for:
Costa, FC
Grant:
2016/08958-7
+ Fundação de Amparo à Pesquisa do Estado de São Paulo
More from this funder
Funding agency for:
Calderano, SG
Grant:
2016/21283-9
+ Medical Research Council
More from this funder
Funding agency for:
Beneke, T
Grant:
15/16_MSD_836338
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Neglected Tropical Diseases Journal website
- Volume:
- 12
- Issue:
- 4
- Article number:
- e0006388
- Publication date:
- 2018-04-02
- Acceptance date:
- 2018-03-14
- DOI:
- EISSN:
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1935-2735
- ISSN:
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1935-2727
- Pmid:
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29608569
- Source identifiers:
-
834032
Item Description
- Language:
- English
- Pubs id:
-
pubs:834032
- UUID:
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uuid:64dcee91-bcd7-482d-a7b9-6b666e02916b
- Local pid:
- pubs:834032
- Deposit date:
- 2018-05-09
Terms of use
- Copyright holder:
- © 2018 Costa et al
- Copyright date:
- 2018
- Notes:
- This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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