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Journal article

RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.

Abstract:

During replication-coupled DNA interstrand crosslink (ICL) repair, the XPF-ERCC1 endonuclease is required for the incisions that release, or "unhook", ICLs, but the mechanism of ICL unhooking remains largely unknown. Incisions are triggered when the nascent leading strand of a replication fork strikes the ICL Here, we report that while purified XPF-ERCC1 incises simple ICL-containing model replication fork structures, the presence of a nascent leading strand, modelling the effects of replicat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embj.201796664

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
Expand authors...
Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Article number:
e201796664
Publication date:
2017-06-12
Acceptance date:
2016-05-19
DOI:
EISSN:
1460-2075
Source identifiers:
700631
Language:
English
Keywords:
Pubs id:
pubs:700631
UUID:
uuid:65133b95-7b96-4fe0-9b26-5e000080fb19
Local pid:
pubs:700631
Deposit date:
2017-06-20

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