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The role of the planar cell polarity pathway in branching morphogenesis

Abstract:

The development of organs such as the lung and kidney occurs by branching morphogenesis. Changes in the cytoskeletal architecture, cell-cell adhesion and cell polarity are necessary for the formation of new branches. Interactions and reciprocal signalling between epithelial and mesenchymal cells mediate these organised cell movements that give rise to a complex system of tubes suitable for the transport of gas or fluids. Mutations that disrupt formation of either the correct number, or shap...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Wolfson College
Role:
Author
More by this author
Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:65200972-a024-4b68-bfd3-a857ec8d99d8
Local pid:
ora:5418
Deposit date:
2011-06-08

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