Journal article
Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control
- Abstract:
-
G-Protein coupled receptors (GPCRs) activate intracellular signalling pathways by coupling to heterotrimeric G-proteins that control many physiological processes including blood pressure homeostasis. The Regulator of G-Protein Signalling-1 (RGS1) controls the magnitude and duration of downstream GPCR signalling by acting as a GTPase-activating protein for specific Gα-proteins. RGS1 has contrasting roles in haematopoietic and non-haematopoietic cells. Rgs1-/-ApoE-/- mice are protected from Ang...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
National Institute for Health Research
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Vascular Pharmacology Journal website
- Volume:
- 108
- Issue:
- 1
- Pages:
- 15-22
- Publication date:
- 2018-04-11
- Acceptance date:
- 2018-04-05
- DOI:
- EISSN:
-
1879-3649
- ISSN:
-
1537-1891
- Pmid:
-
29654907
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:842267
- UUID:
-
uuid:652ae245-0ead-4db1-9ae3-1a5acf44066a
- Local pid:
- pubs:842267
- Source identifiers:
-
842267
- Deposit date:
- 2018-07-24
Terms of use
- Copyright holder:
- Patel et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
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