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Journal article

Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control

Abstract:

G-Protein coupled receptors (GPCRs) activate intracellular signalling pathways by coupling to heterotrimeric G-proteins that control many physiological processes including blood pressure homeostasis. The Regulator of G-Protein Signalling-1 (RGS1) controls the magnitude and duration of downstream GPCR signalling by acting as a GTPase-activating protein for specific Gα-proteins. RGS1 has contrasting roles in haematopoietic and non-haematopoietic cells. Rgs1-/-ApoE-/- mice are protected from Ang...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.vph.2018.04.002

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0002-1361-9174
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0002-1043-4342
National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Vascular Pharmacology Journal website
Volume:
108
Issue:
1
Pages:
15-22
Publication date:
2018-04-11
Acceptance date:
2018-04-05
DOI:
EISSN:
1879-3649
ISSN:
1537-1891
Pmid:
29654907
Source identifiers:
842267
Language:
English
Keywords:
Pubs id:
pubs:842267
UUID:
uuid:652ae245-0ead-4db1-9ae3-1a5acf44066a
Local pid:
pubs:842267
Deposit date:
2018-07-24

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