Characterising the cell biology of leukemic stem cells in acute myeloid leukemia.

Thesis

Acute Myeloid leukemia (AML) is an aggressive haematological malignancy that mainly affects the elderly. Relapse is common and is thought to be due to the presence of chemotherapy resistant leukemic stem cells (LSC). Within the CD34+ disease (>5% of the blast cells expressing CD34) , two subtypes have been identified; an LMPP/GMPlike expanded type and a MPP/CMP-like expanded type, the former is the most common, accounting for around 80% of CD34+ AML. Both the GMP-like and LMPPlike expan...

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Authors: Cornforth, T; Terri Cornforth

• Publication date: 2013
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: acute myeloid leukemia; microRNAs; leukemic stem cells
• Subjects: Blood; Life Sciences; Haematology; Clinical laboratory sciences; Biology (medical sciences); Molecular haematology; Biology; Stem cells (clinical sciences)