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Description of HLA class I- and CD8-deficient patients: Insights into the function of cytotoxic T lymphocytes and NK cells in host defense.

Abstract:
Over the last few years, several patients with defects in the HLA class I presentation pathway have been described. Analysis of their clinical symptoms and immunological parameters have led to the identification of several unexpected findings which are of importance to understand the role of HLA class I-dependent immune responses in host defense. Here, we will describe and compare clinical manifestations and immunological findings of patients with defects in the peptide transporter proteins (TAP complex), tapasin and CD8 molecules.
Publication status:
Published

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Publisher copy:
10.1016/j.smim.2006.07.006

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
Seminars in immunology
Volume:
18
Issue:
6
Pages:
330-336
Publication date:
2006-12-01
DOI:
EISSN:
1096-3618
ISSN:
1044-5323
Source identifiers:
33599
Language:
English
Keywords:
Pubs id:
pubs:33599
UUID:
uuid:657f6062-4484-4622-bc34-9735df1b8de9
Local pid:
pubs:33599
Deposit date:
2012-12-19

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