Journal article
Requirements for driving antipathogen effector genes into populations of disease vectors by homing.
- Abstract:
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There is a need for new interventions against the ongoing burden of vector-borne diseases such as malaria and dengue. One suggestion has been to develop genes encoding effector molecules that block parasite development within the vector, and then use the nuclease-based homing reaction as a form of gene drive to spread those genes through target populations. If the effector gene reduces the fitness of the mosquito and does not contribute to the drive, then loss-of-function mutations in the eff...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.4MB)
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- Publisher copy:
- 10.1534/genetics.116.197632
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Authors
Funding
Bill and Melinda Gates Foundation
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Bibliographic Details
- Publisher:
- Genetics Society of America Publisher's website
- Journal:
- Genetics Journal website
- Volume:
- 205
- Issue:
- 4
- Pages:
- 1587-1596
- Publication date:
- 2017-03-01
- Acceptance date:
- 2017-01-20
- DOI:
- EISSN:
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1943-2631
- ISSN:
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0016-6731
- Source identifiers:
-
679645
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:679645
- UUID:
-
uuid:65a8d601-db6c-418c-8c74-456c4248b489
- Local pid:
- pubs:679645
- Deposit date:
- 2017-05-16
Terms of use
- Copyright holder:
- Beaghton et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Beaghton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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