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Requirements for driving antipathogen effector genes into populations of disease vectors by homing.

Abstract:

There is a need for new interventions against the ongoing burden of vector-borne diseases such as malaria and dengue. One suggestion has been to develop genes encoding effector molecules that block parasite development within the vector, and then use the nuclease-based homing reaction as a form of gene drive to spread those genes through target populations. If the effector gene reduces the fitness of the mosquito and does not contribute to the drive, then loss-of-function mutations in the eff...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1534/genetics.116.197632

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Institution:
University of Oxford
Oxford college:
Jesus College
Role:
Author
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Bill and Melinda Gates Foundation More from this funder
Publisher:
Genetics Society of America Publisher's website
Journal:
Genetics Journal website
Volume:
205
Issue:
4
Pages:
1587-1596
Publication date:
2017-03-01
Acceptance date:
2017-01-20
DOI:
EISSN:
1943-2631
ISSN:
0016-6731
Source identifiers:
679645
Language:
English
Keywords:
Pubs id:
pubs:679645
UUID:
uuid:65a8d601-db6c-418c-8c74-456c4248b489
Local pid:
pubs:679645
Deposit date:
2017-05-16

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