Thesis
The role of NK family receptor interactions with HLA-B27 in Ankylosing Spondylitis pathogenesis
- Abstract:
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Possession of the Major Histocompatibility Complex (MHC) allele, HLA-B27 (B27), strongly predisposes to the development of spondyloarthritis. Furthermore, B27 exists as polymorphic variants, with some subtypes (such as B*2705) being more strongly associated with disease than others (B*2709). The immunological function of MHC molecules is to present peptides in a heterotrimeric complex with beta-2-microglobulin (β2m); however, B27 has also been observed to form non-classical (β₂m –free) hom...
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Authors
Contributors
+ Bowness, P
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Kollnberger, S
Division:
MSD
Department:
NDM
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:660f1445-d773-4a4e-91d3-fdadf957795c
- Local pid:
- ora:5665
- Deposit date:
- 2011-09-06
Terms of use
- Copyright holder:
- Giles, J
- Copyright date:
- 2011
- Notes:
- This thesis is not currently available in ORA.
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